
Water fasting, which includes consuming solely water for a number of days, has not too long ago emerged as a fast solution to reset the metabolism, detoxify, and shed weight quickly. However what actually occurs inside your physique after 72 hours with out meals? Dr Sunil Rana, Affiliate Director and Head of Inner Drugs at Asian Hospital, notes that the adjustments are important, annoying, and never all the time helpful.
By the point an individual reaches the 72-hour mark of water fasting, the physique has exhausted its available gasoline sources. “The liver’s glycogen shops are normally depleted inside the first 24 hours, resulting in a gradual fall in blood glucose ranges,” explains Dr Rana. To compensate, counter-regulatory hormones reminiscent of glucagon, cortisol, and development hormone rise, triggering fats breakdown.
“The liver converts free fatty acids launched from fats tissue into ketone our bodies, which start to produce power to the mind and muscular tissues—a state generally known as dietary ketosis,” he provides.
Whereas blood sugar ranges might stabilise at a decrease vary in wholesome people, the physique is below metabolic pressure. “Ketosis at 72 hours is extra pronounced, however the physique remains to be adapting, and this transition could be physiologically annoying—particularly for folks with low dietary reserves,” he cautions.

Do the claimed advantages maintain up?
Proponents of extended fasting usually declare advantages, together with mobile restore, cleansing, and metabolic reset. However Dr Rana urges warning. “There may be some scientific proof that short-term fasting can activate autophagy, a mobile recycling course of, however most strong information comes from animal research or fasting-mimicking diets—not extended water-only fasting in people,” he explains.
In people, the extent to which autophagy is meaningfully activated inside 72 hours—and whether or not it interprets into long-term well being advantages—stays unclear. Any enchancment in metabolic flexibility is usually short-term and normally reverses as soon as regular consuming resumes,” says Dr Rana.
Then again, the dangers are properly documented. Hypoglycaemia, dehydration, dizziness, electrolyte imbalance, and low blood stress are widespread. “With out medical supervision, the physiological stress of a three-day water quick usually outweighs its unproven advantages, making it an unreliable and doubtlessly unsafe well being observe,” he provides.
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Affect on organs, electrolytes, and muscle
After three days with out meals, the pressure on important programs turns into extra evident. Fluid and sodium loss lead the kidneys to preserve water, however dehydration can nonetheless develop. “Electrolyte imbalances—significantly low sodium, potassium, and magnesium—are among the many most instant considerations, as they will have an effect on coronary heart rhythm, nerve signalling, and muscle perform,” Dr Rana explains.
Though the mind adapts to utilizing ketones, many individuals expertise complications, irritability, and diminished focus. Muscle breakdown additionally begins early. “When glucose is scarce, the physique makes use of amino acids from muscle to keep up important glucose manufacturing. Whereas ketosis reduces this want considerably, muscle loss nonetheless happens,” says Dr Rana. Though important muscular tissues reminiscent of the guts and diaphragm are comparatively well-preserved, skeletal muscle loss after 3 days can be clinically significant.
Who ought to keep away from a 3-day water quick?
Dr Rana emphasises that water fasting is unsafe for several groups. “Individuals with diabetes—particularly these on insulin or sulfonylureas—continual kidney illness, coronary heart illness, gout, consuming issues, or those that are underweight shouldn’t try extended fasting,” he warns. Pregnant or breastfeeding girls, older adults, and people on blood stress or anticoagulant drugs are additionally at elevated threat, he provides.
For these looking for metabolic or weight-related advantages, safer, evidence-backed choices exist. “Time-restricted consuming, reminiscent of 14–16 hour day by day fasting, affords many metabolic benefits with far fewer dangers,” Dr Rana notes.
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“Sustainable metabolic well being comes from gradual dietary adjustments, common bodily exercise, ample sleep, and consistency—not excessive fasting,” he provides.
DISCLAIMER: This text relies on info from the general public area and/or the specialists we spoke to. At all times seek the advice of your well being practitioner earlier than beginning any routine.





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